The Induction of the Synthesis of Interferon, CD4 and CD8 T Lymphocytes in Blood and Spleen of Mice after Oral Vaccination with the "Early" Protein HPV16 E2

Dokl Biochem Biophys. 2019 Sep;488(1):316-319. doi: 10.1134/S1607672919050077. Epub 2019 Nov 25.

Abstract

High contents of interferon and CD4 and CD8 T lymphocytes were found in blood and spleen cells of mice after their oral vaccination with the "early" protein of HPV16 E2 by using ELISPOT, Western blot hybridization, and enzyme immunoassay technique. It was concluded that the "early" protein HPV16 E2 is involved in the immune system activation during control of pathogenesis and neoplasia.

MeSH terms

  • Administration, Oral
  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / pathology
  • CD8-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / pathology
  • DNA-Binding Proteins* / immunology
  • DNA-Binding Proteins* / pharmacology
  • HeLa Cells
  • Human papillomavirus 16 / immunology*
  • Humans
  • Interferons / immunology*
  • Mice
  • Oncogene Proteins, Viral* / immunology
  • Oncogene Proteins, Viral* / pharmacology
  • Papillomavirus Vaccines* / immunology
  • Papillomavirus Vaccines* / pharmacology
  • Spleen / immunology*
  • Spleen / pathology
  • Vaccination*

Substances

  • DNA-Binding Proteins
  • E2 protein, Human papillomavirus type 16
  • Oncogene Proteins, Viral
  • Papillomavirus Vaccines
  • Interferons