Bone oxaloma-a localized manifestation of bone oxalosis

Skeletal Radiol. 2020 Apr;49(4):651-655. doi: 10.1007/s00256-019-03348-0. Epub 2019 Nov 25.

Abstract

Oxalosis is a metabolic disorder characterized by the accumulation of calcium oxalate deposits in various organ systems. Bone oxalosis is a systemic manifestation of oxalosis, in which calcium oxalate deposits accumulate in the skeletal system. This report describes a 69-year-old female patient who presented with right hip pain and was later found to have an osseous mass-like lesion in the right proximal femur, with radiographic findings resembling those of a benign bone tumor. CT-guided biopsy and surgical biopsy showed that the mass had pathologic findings typical of bone oxalosis. Because the patient had no predisposing factors for systemic oxalosis and had no hyperoxalemia or hyperoxaluria, she could be diagnosed with localized bone oxalate deposition disease or bone oxaloma rather than bone oxalosis. This is the first report of this clinical entity to present as a benign-appearing bone mass and without any predisposing systemic causes.

Keywords: Bone oxaloma; Bone tumor-like lesion; Localized bone oxalate deposition disease.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biopsy
  • Bone Neoplasms / diagnostic imaging*
  • Bone Neoplasms / etiology*
  • Bone Neoplasms / pathology
  • Bone and Bones / diagnostic imaging
  • Bone and Bones / surgery
  • Calcium Oxalate
  • Female
  • Humans
  • Hyperoxaluria / complications*
  • Hyperoxaluria / diagnosis*
  • Magnetic Resonance Imaging
  • Radiography
  • Radiography, Interventional
  • Tomography, X-Ray Computed

Substances

  • Calcium Oxalate