Quick Recovery of Renal Alterations and Inflammatory Activation after a Marathon

Nayara Panizo González; Javier Eduardo Reque Santivañez; Barbara Hernando Fuster; Eladio J Collado Boira; Ignacio Martinez-Navarro; Óscar Chiva Bartoll; Carlos Hernando Domingo

doi:10.1159/000500510

Quick Recovery of Renal Alterations and Inflammatory Activation after a Marathon

Kidney Dis (Basel). 2019 Oct;5(4):259-265. doi: 10.1159/000500510. Epub 2019 Jul 9.

Authors

Nayara Panizo González^{1

2}, Javier Eduardo Reque Santivañez³, Barbara Hernando Fuster², Eladio J Collado Boira², Ignacio Martinez-Navarro^{4

5}, Óscar Chiva Bartoll⁶, Carlos Hernando Domingo^{6

7}

Affiliations

¹ Hospital Universitario Clínico de Valencia, Valencia, Spain.
² Department of Health Sciences, Jaume I University, Castellón, Spain.
³ General Hospital of Castellón, Castellón, Spain.
⁴ Sports Health Unit, Vithas-Nisa 9 de Octubre Hospital, Valencia, Spain.
⁵ Department of Physical Education and Sport, University of Valencia, Valencia, Spain.
⁶ Department of Education, Jaume I University, Castellón, Spain.
⁷ Sports Service, Jaume I University, Castellón, Spain.

Abstract

Purpose: We evaluated the incidence of acute kidney injury in a cohort of marathon participants.

Methods: We conducted a prospective observational study focused on evaluating the incidence of kidney damage after a marathon, and its evolution in the first 48 h after the marathon in 88 runners who completed the Valencia Marathon.

Results: From the 88 participants, 42 (48.28%) presented with acute kidney injury, mainly grade 1 (95.20%). Microscopic haematuria was observed in 29 runners (33%). Levels of interleukin 6, leukocytes, and neutrophils were markedly increased at the marathon's finish line.

Conclusions: Our results confirmed that there are slight transient changes in glomerular filtration rate and inflammatory activation after a marathon.

Keywords: Acute kidney injury; Inflammatory activation; Kidney damage resolution; Marathon; Microalbuminuria.