Trikoramide A, a Prenylated Cyanobactin from the Marine Cyanobacterium Symploca hydnoides

J Nat Prod. 2019 Dec 27;82(12):3482-3488. doi: 10.1021/acs.jnatprod.9b00675. Epub 2019 Nov 25.

Abstract

A new cyclic decapeptide, trikoramide A (1), has been isolated from samples of the marine cyanobacterium Symploca hydnoides, collected from Bintan Island, Indonesia. Trikoramide A (1) is a C-prenylated cyclotryptophan-containing cyanobactin. Its planar structure was deduced by 1D and 2D NMR spectroscopy as well as HR-MS/MS data. In addition, its absolute configuration was determined by Marfey's method and 2D NOESY NMR spectroscopic analysis. Compound 1 possessed cytotoxicity against the MOLT-4 and AML2 cancer cell lines with IC50 values of 4.8 and 8.2 μM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Cyanobacteria / metabolism*
  • Drug Screening Assays, Antitumor
  • Humans
  • Inhibitory Concentration 50
  • Prenylation
  • Seawater / microbiology*
  • Spectrum Analysis / methods

Substances

  • Antineoplastic Agents