Maternal asthma and the risk of hypertensive disorders of pregnancy: a systematic review and meta-analysis of cohort studies

Hypertens Pregnancy. 2020 Feb;39(1):12-24. doi: 10.1080/10641955.2019.1693591. Epub 2019 Nov 25.

Abstract

Objective: The aim of this study was to demonstrate the association between maternal asthma and the risk of hypertensive disorders of pregnancy.Methods: A systematic search of seven databases was conducted. A meta-analysis was performed to calculate risk ratios and 95% CI using random-effects models.Results: Asthma was associated with an increased risk of pregnancy-induced hypertension (RR 1.45, 95%CI 1.29-1.63), transient hypertension of pregnancy (RR 2.00, 95%CI 1.52-2.63), preeclampsia or eclampsia (RR 1.28, 95%CI 1.25-1.32), preeclampsia (RR 1.43, 95%CI 1.31-1.57) and eclampsia (RR 1.56, 95%CI 1.13-2.15).Conclusion: The meta-analysis illustrated that asthma was significantly increased risk of hypertension during pregnancy.

Keywords: Mother; asthma; hypertension; meta-analysis.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Asthma / complications*
  • Cohort Studies
  • Female
  • Humans
  • Hypertension, Pregnancy-Induced / etiology*
  • Models, Statistical
  • Odds Ratio
  • Pregnancy
  • Risk Factors