Abstract
We propose a novel fluorescence assay method by designing a polymerization-driven DNA dominoes collapse (PDDC) strategy, enabling highly sensitive detection of p53 gene (as a model analyte) and single nucleotide polymorphism analysis.
MeSH terms
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Cell Line, Tumor
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DNA Probes / chemistry*
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DNA Probes / metabolism
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DNA, Neoplasm / analysis*
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DNA, Neoplasm / metabolism
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Fluorescence Resonance Energy Transfer
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Humans
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Inverted Repeat Sequences
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Neoplasms / diagnosis
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Neoplasms / genetics
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Nucleic Acid Hybridization
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Polymerization
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Polymorphism, Single Nucleotide
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Tumor Suppressor Protein p53 / genetics*
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p-Dimethylaminoazobenzene / analogs & derivatives
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p-Dimethylaminoazobenzene / chemistry
Substances
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DNA Probes
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DNA, Neoplasm
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TP53 protein, human
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Tumor Suppressor Protein p53
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4-(4-dimethylaminophenylazo)benzoic acid
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p-Dimethylaminoazobenzene