Food Allergy Immunotherapy with Adjuvants

Rory E Nicolaides; Christopher P Parrish; J Andrew Bird

doi:10.1016/j.iac.2019.09.004

Food Allergy Immunotherapy with Adjuvants

Immunol Allergy Clin North Am. 2020 Feb;40(1):149-173. doi: 10.1016/j.iac.2019.09.004. Epub 2019 Nov 6.

Authors

Rory E Nicolaides¹, Christopher P Parrish¹, J Andrew Bird²

Affiliations

¹ Department of Pediatrics, Division of Allergy and Immunology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9063, USA; Department of Internal Medicine, Division of Allergy and Immunology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9063, USA.
² Department of Pediatrics, Division of Allergy and Immunology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9063, USA; Department of Internal Medicine, Division of Allergy and Immunology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9063, USA. Electronic address: Drew.Bird@utsouthwestern.edu.

PMID: 31761115
DOI: 10.1016/j.iac.2019.09.004

Abstract

Treatment of immunoglobulin E-mediated food allergy has traditionally been limited to allergen avoidance and emergency treatment after accidental ingestion. In recent years, significant progress has been made with oral, sublingual, and epicutaneous immunotherapy in the treatment of food allergy; however, these emerging treatment options have important limitations in efficacy, durability of effect, and safety. These limitations have already spurred interest in the development of adjuvant therapies to increase efficacy, produce more durable immunologic changes, and/or reduce treatment-related adverse reactions.

Keywords: Adjuvant therapy; EPIT; Food allergy; Modified allergens; OIT; SLIT.

Publication types

Review

MeSH terms

Adjuvants, Immunologic / therapeutic use*
Administration, Oral
Allergens / immunology
Animals
Desensitization, Immunologic / methods*
Food
Food Hypersensitivity / immunology
Food Hypersensitivity / therapy*
Humans
Immunoglobulin E / metabolism
Injections, Subcutaneous

Substances

Adjuvants, Immunologic
Allergens
Immunoglobulin E