Roads to Formation of Normal Myelin Structure and Pathological Myelin Structure

Yoshio Bando

doi:10.1007/978-981-32-9636-7_16

Roads to Formation of Normal Myelin Structure and Pathological Myelin Structure

Adv Exp Med Biol. 2019:1190:257-264. doi: 10.1007/978-981-32-9636-7_16.

Author

Yoshio Bando^{1

2}

Affiliations

¹ Department of Functional Anatomy and Neuroscience, Asahikawa Medical University, Asahikawa, Japan. ybando@med.akita-u.ac.jp.
² Department of Anatomy, Akita University Graduate School of Medicine, Akita, Japan. ybando@med.akita-u.ac.jp.

PMID: 31760649
DOI: 10.1007/978-981-32-9636-7_16

Abstract

Demyelination and axonal damage are responsible for neurological deficits in demyelinating diseases including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. However, the pathology of demyelination and axonal damage in MS is not fully understood. While immunologists have accumulated evidence, which is involved in many immunological events in these diseases, neuroscientists and anatomists have also investigated morphological changes of myelin in these diseases. In this chapter, a new concept of demyelination will be described.

Keywords: Axonal degeneration; Demyelination; EAE; MS; Myelin; Oligodendrocyte.

Publication types

Review

MeSH terms

Axons / pathology*
Humans
Multiple Sclerosis / physiopathology*
Myelin Sheath / pathology*
Myelin Sheath / physiology*