MYPT1 Down-regulation by Lipopolysaccharide-SIAH1/2 E3 Ligase-Ubiquitin-Proteasomal Degradation Contributes to Colonic Obstruction of Hirschsprung Disease

W Zhao; P Wang; W He; T Tao; H Li; Y Li; W Jiang; J Sun; X Ge; X Chen; Y Zheng; L Wei; C Chen; Y Wang; C Li; H Chen; B Yao; W Tang; M Zhu

doi:10.1016/j.jcmgh.2019.11.003

MYPT1 Down-regulation by Lipopolysaccharide-SIAH1/2 E3 Ligase-Ubiquitin-Proteasomal Degradation Contributes to Colonic Obstruction of Hirschsprung Disease

Cell Mol Gastroenterol Hepatol. 2020;9(2):345-347.e6. doi: 10.1016/j.jcmgh.2019.11.003. Epub 2019 Nov 20.

Authors

W Zhao¹, P Wang², W He³, T Tao², H Li⁴, Y Li², W Jiang⁴, J Sun², X Ge⁵, X Chen², Y Zheng², L Wei², C Chen², Y Wang², C Li², H Chen⁶, B Yao⁷, W Tang⁸, M Zhu⁹

Affiliations

¹ State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, Ministry of Education (MOE) Key Laboratory of Model Animal for Disease Study and the Medical School of Nanjing University, Nanjing, China; Reproductive Medical Center, Jinling Hospital Affiliated Medical School of Nanjing University, Nanjing, China.
² State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, Ministry of Education (MOE) Key Laboratory of Model Animal for Disease Study and the Medical School of Nanjing University, Nanjing, China.
³ Jiangsu Key Laboratory of Neuropsychiatric Diseases and Cambridge-Suda (CAM-SU) Genomic Resource Center, Soochow University, Suzhou, China.
⁴ Department of Pediatric Surgery, Children's Hospital of Nanjing Medical University, Nanjing, China.
⁵ Department of General Surgery, Sir Run Run Shaw Hospital Affiliated Medical College of Zhejiang University, Hangzhou, China.
⁶ College of Life Science, Nanjing Normal University, Nanjing, China.
⁷ Reproductive Medical Center, Jinling Hospital Affiliated Medical School of Nanjing University, Nanjing, China. Electronic address: yaobing@nju.edu.cn.
⁸ Department of Pediatric Surgery, Children's Hospital of Nanjing Medical University, Nanjing, China. Electronic address: twbcn@njmu.edu.cn.
⁹ State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, Ministry of Education (MOE) Key Laboratory of Model Animal for Disease Study and the Medical School of Nanjing University, Nanjing, China. Electronic address: zhums@nju.edu.cn.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Colon / pathology
Colon / surgery
Disease Models, Animal
Down-Regulation
Female
Hirschsprung Disease / complications*
Hirschsprung Disease / surgery
Humans
Infant
Intestinal Obstruction / etiology
Intestinal Obstruction / pathology*
Intestinal Obstruction / surgery
Laparoscopy
Lipopolysaccharides / metabolism
Male
Mice
Mice, Knockout
Muscle Contraction
Muscle, Smooth / pathology
Muscle, Smooth / surgery
Myosin-Light-Chain Phosphatase / metabolism*
Nuclear Proteins / metabolism
Proteasome Endopeptidase Complex / metabolism
Receptor, Endothelin B / genetics
Signal Transduction
Transanal Endoscopic Surgery
Ubiquitin / metabolism
Ubiquitin-Protein Ligases / metabolism

Substances

EDNRB protein, mouse
Lipopolysaccharides
Nuclear Proteins
Receptor, Endothelin B
Ubiquitin
Ubiquitin-Protein Ligases
seven in absentia proteins
Myosin-Light-Chain Phosphatase
PPP1R12A protein, human
Ppp1r12a protein, mouse
Proteasome Endopeptidase Complex