Novel mechanism of increasing cerebral vascular constriction in acute hyperglycemia and diabetes through adenylyl cyclase 5-generated cyclic adenosine monophosphate

J Diabetes Investig. 2020 Jul;11(4):783-785. doi: 10.1111/jdi.13186. Epub 2019 Dec 23.

Authors

Kenichi Sakamoto^{1

2}, Koutaro Yokote^{1

3}

Affiliations

¹ Department of Endocrinology, Hematology, and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
² Department of Medicine, Diabetes, Obesity and Metabolism Institute (DOMI), Icahn School of Medicine at Mt Sinai, New York City, New York, USA.
³ Division of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, Chiba, Japan.

No abstract available

MeSH terms

Acute Disease
Adenylyl Cyclases / metabolism*
Cerebrovascular Circulation / physiology*
Constriction
Cyclic AMP / metabolism*
Diabetes Mellitus, Type 2 / complications
Diabetes Mellitus, Type 2 / physiopathology*
Humans
Hyperglycemia / etiology
Hyperglycemia / physiopathology*

Substances

Cyclic AMP
Adenylyl Cyclases
adenylyl cyclase type V