Comparative lipidomics analysis of human, bovine and caprine milk by UHPLC-Q-TOF-MS

Lina Wang; Xiaodong Li; Lu Liu; Hong da Zhang; Yu Zhang; Yu Hao Chang; Qi Peng Zhu

doi:10.1016/j.foodchem.2019.125865

Comparative lipidomics analysis of human, bovine and caprine milk by UHPLC-Q-TOF-MS

Food Chem. 2020 Apr 25:310:125865. doi: 10.1016/j.foodchem.2019.125865. Epub 2019 Nov 9.

Authors

Lina Wang¹, Xiaodong Li², Lu Liu³, Hong da Zhang¹, Yu Zhang¹, Yu Hao Chang¹, Qi Peng Zhu¹

Affiliations

¹ Food College, Northeast Agricultural University, No. 600 Changjiang St. Xiangfang Dist, 150030 Harbin, China; Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, No. 600 Changjiang St. Xiangfang Dist, 150030 Harbin, China.
² Food College, Northeast Agricultural University, No. 600 Changjiang St. Xiangfang Dist, 150030 Harbin, China; Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, No. 600 Changjiang St. Xiangfang Dist, 150030 Harbin, China. Electronic address: hrblxd@163.com.
³ Food College, Northeast Agricultural University, No. 600 Changjiang St. Xiangfang Dist, 150030 Harbin, China; Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, No. 600 Changjiang St. Xiangfang Dist, 150030 Harbin, China. Electronic address: liulu89824@163.com.

PMID: 31757488
DOI: 10.1016/j.foodchem.2019.125865

Abstract

Although infant formula represents an important human milk substitute, it has been shown to contain many different lipid structures compared to human milk. In this study, the lipidome and fatty acid composition of human, bovine and caprine milk were analyzed and compared. A total of 13 lipid classes (including TG, DG, SM, PC, Cer, HexCer, Hex₂Cer, PE, PG, PS, PI, PA and CL) were analyzed. Human milk was richer in TG containing LA, SM containing ULCFA and PLs containing ARA, DHA and DGLA. Moreover, there were no differential DG and SM species between human and caprine milk. A total of 215 and 147 lipids were identified as potential biomarkers that could be used to further analyze differences in the biological properties of human, bovine and caprine milk. This comprehensive analysis will hopefully help in the design of infant formula more suitable for Chinese babies.

Keywords: Bovine milk; Caprine milk; Fatty acid; Human milk; Lipidomics.

Publication types

Comparative Study

MeSH terms

Animals
Cattle
Chromatography, High Pressure Liquid / methods*
Fatty Acids / analysis
Goats
Humans
Lipidomics*
Lipids / analysis
Mass Spectrometry / methods*
Milk / chemistry*

Substances

Fatty Acids
Lipids