IL-38 is a biomarker for acute respiratory distress syndrome in humans and down-regulates Th17 differentiation in vivo

Yu-Sen Chai; Shi-Hui Lin; Mu Zhang; Liangyong Deng; Yanqing Chen; Ke Xie; Chuan-Jiang Wang; Fang Xu

doi:10.1016/j.clim.2019.108315

IL-38 is a biomarker for acute respiratory distress syndrome in humans and down-regulates Th17 differentiation in vivo

Clin Immunol. 2020 Jan:210:108315. doi: 10.1016/j.clim.2019.108315. Epub 2019 Nov 20.

Authors

Yu-Sen Chai¹, Shi-Hui Lin², Mu Zhang², Liangyong Deng³, Yanqing Chen¹, Ke Xie¹, Chuan-Jiang Wang⁴, Fang Xu⁵

Affiliations

¹ Department of Critical Care Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China; The Chongqing Key Laboratory of Translation Medicine in Major Metabolic Diseases, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
² The Chongqing Key Laboratory of Translation Medicine in Major Metabolic Diseases, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
³ Department of Pathology, Chongqing Medical University, China.
⁴ The Chongqing Key Laboratory of Translation Medicine in Major Metabolic Diseases, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: wangchuanjiang@cqmu.edu.cn.
⁵ Department of Critical Care Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China; The Chongqing Key Laboratory of Translation Medicine in Major Metabolic Diseases, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Department of pathophysiology, School of Basic Medical Sciences of Chongqing Medical University, Chongqing, China. Electronic address: xufang828@126.com.

PMID: 31756565
DOI: 10.1016/j.clim.2019.108315

No abstract available

Keywords: Acute respiratory distress syndrome; Cytokines; IL-17A; Interleukin-38; Signal transducer and activator of transcription 3; T helper cell 17; Uncontrolled inflammation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Animals
Antibodies, Blocking / administration & dosage
Biomarkers / metabolism*
Cell Differentiation
Cells, Cultured
Down-Regulation
Female
Humans
Interleukins / metabolism*
Male
Mice
Mice, Inbred C57BL
Middle Aged
Respiratory Distress Syndrome / diagnosis*
Respiratory Distress Syndrome / immunology
Th17 Cells / immunology*

Substances

Antibodies, Blocking
Biomarkers
IL-38 protein, human
Interleukins