Antioxidative system of Deinococcus radiodurans

Hui-Zhou Qi; Wu-Zhou Wang; Jun-Yan He; Yun Ma; Fang-Zhu Xiao; Shu-Ya He

doi:10.1016/j.resmic.2019.11.002

Antioxidative system of Deinococcus radiodurans

Res Microbiol. 2020 Mar;171(2):45-54. doi: 10.1016/j.resmic.2019.11.002. Epub 2019 Nov 19.

Authors

Hui-Zhou Qi¹, Wu-Zhou Wang², Jun-Yan He², Yun Ma³, Fang-Zhu Xiao⁴, Shu-Ya He⁵

Affiliations

¹ Institute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China, Hengyang, 421001, China; Function Laboratory Center, Hengyang Medical College, University of South China, Hengyang, 421001, China; Hengyang Key Laboratory for Biological Effects of Nuclear Radiation, University of South China, Hengyang, 421001, China.
² Institute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China, Hengyang, 421001, China; Hengyang Key Laboratory for Biological Effects of Nuclear Radiation, University of South China, Hengyang, 421001, China.
³ Institute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China, Hengyang, 421001, China.
⁴ Hengyang Key Laboratory for Biological Effects of Nuclear Radiation, University of South China, Hengyang, 421001, China.
⁵ Institute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China, Hengyang, 421001, China; Hengyang Key Laboratory for Biological Effects of Nuclear Radiation, University of South China, Hengyang, 421001, China. Electronic address: heshuya8502@163.com.

PMID: 31756434
DOI: 10.1016/j.resmic.2019.11.002

Abstract

Deinococcus radiodurans is famous for its extreme resistance to various stresses such as ionizing radiation (IR), desiccation and oxidative stress. The underlying mechanism of exceptional resistance of this robust bacterium still remained unclear. However, the antioxidative system of D. radiodurans has been considered to be the determinant factor for its unparalleled resistance and protects the proteome during stress, then the DNA repair system and metabolic system exert their functions to restore the cell to normal physiological state. The antioxidative system not only equipped with the common reactive oxygen species (ROS) scavenging enzymes (e.g., catalase and superoxide dismutase) but also armed with a variety of non-enzyme antioxidants (e.g., carotenoids and manganese species). And the small manganese complexes play an important role in the antioxidative system of D. radiodurans. Recent studies have characterized several regulators (e.g., PprI and PprM) in D. radiodurans, which play critical roles in the protection of the bacteria from various stresses. In this review, we offer a panorama of the progress regarding the characteristics of the antioxidative system in D. radiodurans and its application in the future.

Keywords: Antioxidative system; Deinococcus radiodurans; Manganese; PprI; PprM; Reactive oxygen species.

Publication types

Review

MeSH terms

Antioxidants / metabolism*
Biological Transport
DNA Repair
Deinococcus / genetics
Deinococcus / metabolism*
Gene Expression Regulation, Bacterial
Gene Expression Regulation, Enzymologic
Homeostasis
Oxidative Stress
Reactive Oxygen Species / metabolism

Substances

Antioxidants
Reactive Oxygen Species