Peniterester, a carotane-type antibacterial sesquiterpene from an artificial mutant Penicillium sp. T2-M20

Rong-Ting Duan; Rui-Ning Yang; Hong-Tao Li; Lin-Huan Tang; Tao Liu; Ya-Bin Yang; Hao Zhou; Zhong-Tao Ding

doi:10.1016/j.fitote.2019.104422

Peniterester, a carotane-type antibacterial sesquiterpene from an artificial mutant Penicillium sp. T2-M20

Fitoterapia. 2020 Jan:140:104422. doi: 10.1016/j.fitote.2019.104422. Epub 2019 Nov 19.

Authors

Rong-Ting Duan¹, Rui-Ning Yang¹, Hong-Tao Li¹, Lin-Huan Tang¹, Tao Liu¹, Ya-Bin Yang¹, Hao Zhou², Zhong-Tao Ding³

Affiliations

¹ Key Laboratory of Functional Molecules Analysis and Biotransformation of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
² Key Laboratory of Functional Molecules Analysis and Biotransformation of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China. Electronic address: haozhou@ynu.edu.cn.
³ Key Laboratory of Functional Molecules Analysis and Biotransformation of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China. Electronic address: ztding@ynu.edu.cn.

PMID: 31756377
DOI: 10.1016/j.fitote.2019.104422

Abstract

Peniterester (1), a new tricyclic sesquiterpene, together with 6 known compounds (2-7) were isolated from the secondary metabolites of an artificial mutant Penicillium sp. T2-M20 which was obtained from the parental strain Penicillium sp. T2-8 via UV irradiation as well as nitrosoguanidine (NTG) induction. Peniterester was only produced by the mutant T2-M20 on the basis of LC-MS analysis. Meanwhile, the results of in vitro bioactivities screening indicated that peniterester owned obvious antibacterial activities against Bacillus subtilis, Escherichia coli and Staphylococcus aureus with MICs of 8.0, 8.0 and 4.0 μg/mL, respectively.

Keywords: Antibacterial activity; Artificial mutation; Penicillium sp.; Secondary metabolites; Sesquiterpene.

MeSH terms

Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology*
Bacillus subtilis / drug effects
Cell Line, Tumor
China
Escherichia coli / drug effects
Gastrodia / microbiology
Humans
Microbial Sensitivity Tests
Molecular Structure
Penicillium / chemistry*
Rhizome / microbiology
Secondary Metabolism
Sesquiterpenes / isolation & purification
Sesquiterpenes / pharmacology*
Staphylococcus aureus / drug effects

Substances

Anti-Bacterial Agents
Sesquiterpenes