Enzyme Allostery: Now Controllable by Light

Taylor M Courtney; Alexander Deiters

doi:10.1016/j.chembiol.2019.11.001

Enzyme Allostery: Now Controllable by Light

Cell Chem Biol. 2019 Nov 21;26(11):1481-1483. doi: 10.1016/j.chembiol.2019.11.001.

Authors

Taylor M Courtney¹, Alexander Deiters²

Affiliations

¹ Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
² Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address: deiters@pitt.edu.

Abstract

In this issue of Cell Chemical Biology, the Sterner lab reports the application of photoswitchable unnatural amino acids in controlling protein allostery in the enzyme complex imidazole glycerol phosphate synthase (Kneuttinger et al., 2019). Remarkable switching in enzyme activity was achieved upon photoisomerization of an azobenzene amino acid.

Publication types

Comment

MeSH terms

Amino Acids*

Substances

Amino Acids

Grants and funding

R01 GM132565/GM/NIGMS NIH HHS/United States