Diterpenoids from Euphorbia neriifolia and Their Related Anti-HIV and Cytotoxic Activity

Chem Biodivers. 2019 Dec;16(12):e1900495. doi: 10.1002/cbdv.201900495. Epub 2019 Nov 22.

Abstract

Fifteen diterpenoids (1-15), including three undescribed ones with ent-atisane skeleton, eupnerias G-I (1-3), were obtained from Euphorbia neriifolia. Compounds 1-3 were established through comprehensive spectroscopic analysis. Compounds 4 and 5 exhibited obvious anti-HIV-1 effect, and their EC50 were 6.6±3.2 and 6.4±2.5 μg mL-1 , respectively. Compound 6 exhibited moderate cytotoxicity on HepG2 and HepG2/Adr cells with IC50 at 13.70 and 15.57 μm, respectively. In addition, compound 15 exhibited significant cytotoxicity on HepG2 cell lines (IC50 =0.01 μm), while it did not show any cytotoxicity against HepG2/Adr cell lines.

Keywords: Euphorbia neriifolia; anti-HIV, cytotoxic activity; ent-atisane diterpenoids.

MeSH terms

  • Anti-HIV Agents / chemistry*
  • Anti-HIV Agents / pharmacology
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Diterpenes / chemistry*
  • Diterpenes / pharmacology
  • Drug Resistance, Neoplasm / drug effects
  • Euphorbia / chemistry*
  • Euphorbia / metabolism
  • HIV-1 / drug effects
  • Humans
  • Molecular Conformation
  • Structure-Activity Relationship

Substances

  • Anti-HIV Agents
  • Antineoplastic Agents, Phytogenic
  • Diterpenes