Rhizophols A and B, antioxidant and axially chiral benzophenones from the endophytic fungus Cytospora rhizophorae

Org Biomol Chem. 2019 Dec 4;17(47):10009-10012. doi: 10.1039/c9ob02282a.

Abstract

Two novel polyketones, rhizophols A-B (1-2), were isolated from the endophytic fungus Cytospora rhizophorae A761. They shared unprecedented poly-substituted benzophenone skeletons featuring an epoxy isopentyl unit and a propionyl moiety. Their structures were evidenced by extensive spectroscopic analyses, X-ray diffraction, and quantum energy calculation. Moreover, compound 1 was proved to be a promising lead compound for novel antioxidant drugs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemical synthesis
  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Ascomycota / chemistry*
  • Benzophenones / chemical synthesis
  • Benzophenones / chemistry
  • Benzophenones / pharmacology*
  • Biphenyl Compounds / antagonists & inhibitors*
  • Crystallography, X-Ray
  • Models, Molecular
  • Molecular Conformation
  • Picrates / antagonists & inhibitors*
  • Quantum Theory

Substances

  • Antioxidants
  • Benzophenones
  • Biphenyl Compounds
  • Picrates
  • 1,1-diphenyl-2-picrylhydrazyl