Abstract
Two novel polyketones, rhizophols A-B (1-2), were isolated from the endophytic fungus Cytospora rhizophorae A761. They shared unprecedented poly-substituted benzophenone skeletons featuring an epoxy isopentyl unit and a propionyl moiety. Their structures were evidenced by extensive spectroscopic analyses, X-ray diffraction, and quantum energy calculation. Moreover, compound 1 was proved to be a promising lead compound for novel antioxidant drugs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antioxidants / chemical synthesis
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Antioxidants / chemistry
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Antioxidants / pharmacology*
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Ascomycota / chemistry*
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Benzophenones / chemical synthesis
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Benzophenones / chemistry
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Benzophenones / pharmacology*
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Biphenyl Compounds / antagonists & inhibitors*
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Crystallography, X-Ray
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Models, Molecular
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Molecular Conformation
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Picrates / antagonists & inhibitors*
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Quantum Theory
Substances
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Antioxidants
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Benzophenones
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Biphenyl Compounds
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Picrates
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1,1-diphenyl-2-picrylhydrazyl