Poly hydroxyalkanoates (PHA): Role in bone scaffolds

Ruby Dwivedi; Rahul Pandey; Sumit Kumar; Divya Mehrotra

doi:10.1016/j.jobcr.2019.10.004

Poly hydroxyalkanoates (PHA): Role in bone scaffolds

J Oral Biol Craniofac Res. 2020 Jan-Mar;10(1):389-392. doi: 10.1016/j.jobcr.2019.10.004. Epub 2019 Nov 5.

Authors

Ruby Dwivedi¹, Rahul Pandey², Sumit Kumar², Divya Mehrotra²

Affiliations

¹ Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, KGMU, Lucknow, UP, India.
² DHR-MRU, Faculty of Dental Sciences, KGMU, Lucknow, UP, India.

Abstract

Polyhydroxyalkanoates (PHA) are prokaryotic macromolecules accumulated within the cytoplasm as granules. Due to their suitable mechanical properties, biocompatibility, degradation time, ability to be blended, surface modified, and form copolymers, it is widely used in medical devices and as scaffolds in bone tissue engineering. This review describes in brief the production and extraction sources, physico-chemical characteristic, mechanical properties, degradation rate and applications of various PHAs and its copolymers with special emphasis to its role as scaffolds in bone tissue engineering.

Keywords: Bone tissue engineering; Polyhydroxyalkanoates; Polyhydroxybutyrate; Scaffolds.

Publication types

Review