Helminths Turning on the NLRP3 Inflammasome: Pros and Cons

Daiana Pamela Celias; Claudia Cristina Motrán; Laura Cervi

doi:10.1016/j.pt.2019.10.012

Helminths Turning on the NLRP3 Inflammasome: Pros and Cons

Trends Parasitol. 2020 Feb;36(2):87-90. doi: 10.1016/j.pt.2019.10.012. Epub 2019 Nov 18.

Authors

Daiana Pamela Celias¹, Claudia Cristina Motrán², Laura Cervi³

Affiliations

¹ Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba; Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI), CONICET, Córdoba, Argentina. Electronic address: dcelias@fcq.unc.edu.ar.
² Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba; Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI), CONICET, Córdoba, Argentina.
³ Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba; Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI), CONICET, Córdoba, Argentina. Electronic address: lcervi@fcq.unc.edu.ar.

PMID: 31753545
DOI: 10.1016/j.pt.2019.10.012

Abstract

Helminth infections can activate multimeric protein complexes called inflammasomes. In this forum we summarize the main effects of the NLRP3 inflammasome activation, including control of excessive Th2 response and immunopathology induction. These mechanisms would ensure the survival of both the host and the parasite.

Keywords: helminths; immunopathology; inflammasome activation.

Publication types

Review

MeSH terms

Animals
Helminthiasis / immunology*
Helminthiasis / parasitology*
Helminths / immunology*
Host-Parasite Interactions / immunology*
Humans
Inflammasomes / immunology*
NLR Family, Pyrin Domain-Containing 3 Protein / immunology*

Substances

Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein