Glycolic acid: Characterization of a new final irrigant and effects on flexural strength and structural integrity of dentin

Mater Sci Eng C Mater Biol Appl. 2020 Jan:106:110283. doi: 10.1016/j.msec.2019.110283. Epub 2019 Oct 7.

Abstract

The aim of this study was to characterize glycolic acid (GA) and examine its effects on powder and flexural strength of dentin. Particle size and energy-dispersive EDS in GA powder was performed for chemical analysis. Surface tension and pH levels of ethylenediaminetetraacetic acid (EDTA), citric acid (CA), and GA solutions were evaluated at different times and temperatures. Dentin powder and mineralized dentin beams were immersed for 1 min in EDTA, CA, or GA solutions and subjected to Fourier transform infrared spectroscopy for apatite/collagen ratio analysis and 3-point flexure test, respectively. GA showed the largest particle size (μm), and its surface tension was similar to that of EDTA and CA. Surface tension decreased in solutions of higher concentrations. GA showed pH stability at all times and temperatures evaluated. The apatite/collagen ratio reduced with increased GA concentrations, while flexural strength was not significantly affected by GA concentration. GA seems a good choice as a final irrigation solution after root canal preparation.

Keywords: Citric acid; Dentin; EDTA; Endodontics; Glycolic acid.

MeSH terms

  • Citric Acid / chemistry
  • Collagen / chemistry
  • Collagen / metabolism
  • Dental Pulp Cavity / drug effects
  • Dentin / chemistry*
  • Dentin / drug effects
  • Edetic Acid / chemistry
  • Flexural Strength
  • Glycolates / chemistry*
  • Glycolates / pharmacology
  • Humans
  • Hydrogen-Ion Concentration
  • Particle Size
  • Protein Denaturation
  • Root Canal Irrigants / chemistry
  • Root Canal Irrigants / pharmacology
  • Surface Tension
  • Temperature

Substances

  • Glycolates
  • Root Canal Irrigants
  • glycolic acid
  • Citric Acid
  • Collagen
  • Edetic Acid