Frequent Offenders and Patterns of Injury

Jinyu Zhang; Deepak Venkat

doi:10.1016/j.cld.2019.09.002

Frequent Offenders and Patterns of Injury

Clin Liver Dis. 2020 Feb;24(1):37-48. doi: 10.1016/j.cld.2019.09.002. Epub 2019 Oct 28.

Authors

Jinyu Zhang¹, Deepak Venkat²

Affiliations

¹ Division of Gastroenterology and Hepatology, Department of Medicine, Henry Ford Hospital, 2799 West Grand Boulevard K-7, Detroit, MI 48202, USA.
² Division of Gastroenterology and Hepatology, Department of Medicine, Henry Ford Hospital, 2799 West Grand Boulevard K-7, Detroit, MI 48202, USA. Electronic address: Dvenkat1@hfhs.org.

PMID: 31753249
DOI: 10.1016/j.cld.2019.09.002

Abstract

Given the liver's role in drug metabolism, it is uniquely sensitive to potential drug-induced liver injury (DILI) despite inherent protective mechanisms. In this article, we focus on the most common causes of DILI and their patterns of injury. Although not comprehensive, we attempt to cover several classes of commonly used drugs, and their associated patterns of injury and management.

Keywords: Amiodarone; Antiepileptics; Antimicrobials; DILI; Immunotherapies.

Publication types

Review

MeSH terms

Chemical and Drug Induced Liver Injury* / etiology
Chemical and Drug Induced Liver Injury* / metabolism
Chemical and Drug Induced Liver Injury* / therapy
Humans
Patient Care Management / methods
Pharmaceutical Preparations* / classification
Pharmaceutical Preparations* / metabolism
Pharmacokinetics
Risk Factors

Substances

Pharmaceutical Preparations