Surgical Considerations and Systemic Therapy of Melanoma

Surg Clin North Am. 2020 Feb;100(1):141-159. doi: 10.1016/j.suc.2019.09.012. Epub 2019 Nov 1.

Abstract

Recent advances in effective medical therapies have markedly improved the prognosis for patients with advanced melanoma. This article aims to highlight the current era of integrated multidisciplinary care of patients with advanced melanoma by outlining current approved therapies, including immunotherapy, targeted therapy, radiation therapy, and other strategies used in both the adjuvant and the neoadjuvant setting as well as the evolving role of surgical intervention in the changing landscape of advanced melanoma.

Keywords: Adjuvant therapy; Advanced melanoma; Immunotherapy; Neoadjuvant therapy; Targeted therapy.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents, Immunological / therapeutic use
  • Combined Modality Therapy
  • Humans
  • Immunotherapy
  • Melanoma / pathology
  • Melanoma / therapy*
  • Prognosis
  • Skin Neoplasms / pathology
  • Skin Neoplasms / therapy*

Substances

  • Antineoplastic Agents, Immunological