Cellular Attachment and Entry Factors for Chikungunya Virus

Viruses. 2019 Nov 19;11(11):1078. doi: 10.3390/v11111078.

Abstract

Chikungunya virus (CHIKV) is clinically the most relevant member of the Alphavirus genus. Like alphaviruses in general, CHIKV has the capacity to infect a large variety of cells, tissues, and species. This broad host tropism of CHIKV indicates that the virus uses a ubiquitously expressed receptor to infect cells. This review summarizes the current knowledge available on cellular CHIKV receptors and the attachment factors used by CHIKV.

Keywords: alphavirus; chikungunya virus; receptor.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Line
  • Chikungunya Fever / virology*
  • Chikungunya virus / physiology*
  • Host-Pathogen Interactions*
  • Humans
  • Models, Biological
  • Viral Tropism
  • Virus Attachment*
  • Virus Internalization*
  • Virus Replication