Mushroom lectins in biomedical research and development

Abstract

Lectins are unique biorecognition proteins which recognize and interact with various cell surface carbohydrates/glycoproteins. These ubiquitous molecules are involved in various cell-cell interactions and can be exploited to analyze cell surface associated interactions and biological functions. Amongst fungi, lectins have been extensively explored from mushrooms as compared to microfungi or yeasts. Lectins from basidiomycetes have diverse features in terms of their physico-chemical characteristics and carbohydrate specificity. A plethora of lectins from genera Aleuria, Agrocybe, Boletus, Pleurotus, Russula, Schizophyllum, Volvariella, etc. exhibit potential applications in biomedical field. The current review summarizes the potential sources and characteristics of mushroom lectins. Potential involvement of mushroom lectin as anticancer, mitogenic, antiviral, antimicrobial, antioxidant and therapeutic agents has been discussed.

Keywords: Antiproliferative; Antiviral; Immunomodulatory; Lectins; Mushrooms.