Precision Medicine and Precision Public Health in the Era of Pathogen Next-Generation Sequencing

Mariana Leguia; Anton Vila-Sanjurjo; Patrick S G Chain; Irina Maljkovic Berry; Richard G Jarman; Simon Pollett

doi:10.1093/infdis/jiz424

Precision Medicine and Precision Public Health in the Era of Pathogen Next-Generation Sequencing

J Infect Dis. 2020 Mar 28;221(Suppl 3):S289-S291. doi: 10.1093/infdis/jiz424.

Authors

Mariana Leguia¹, Anton Vila-Sanjurjo², Patrick S G Chain³, Irina Maljkovic Berry⁴, Richard G Jarman⁴, Simon Pollett^{4

5}

Affiliations

¹ Laboratorio de Genómica, Pontificia Universidad Católica del Perú, Lima.
² Departamento de Bioloxía Celular e Molecular, Facultade de Ciencias, Universidade de A Coruña, Spain.
³ Bioscience Division, Los Alamos National Laboratory, New Mexico.
⁴ Walter Reed Army Institute of Research, Silver Spring, Maryland.
⁵ Department of Preventive Medicine and Biostatistics (Uniformed Services University of the Health Sciences), Bethesda, Maryland.

Abstract

This brief report serves as an introduction to a supplement of the Journal of Infectious Diseases entitled "Next-Generation Sequencing (NGS) Technologies to Advance Global Infectious Disease Research." We briefly discuss the history of NGS technologies and describe how the techniques developed during the past 40 years have impacted our understanding of infectious diseases. Our focus is on the application of NGS in the context of pathogen genomics. Beyond obvious clinical and public health applications, we also discuss the challenges that still remain within this rapidly evolving field.

Keywords: infectious diseases; next-generation sequencing; pathogen genomics.

Publication types

Introductory Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Communicable Diseases / microbiology*
Communicable Diseases / parasitology
Communicable Diseases / virology
Genomics*
High-Throughput Nucleotide Sequencing*
Humans
Precision Medicine*
Public Health*