An overview of motor unit number index reproducibility in amyotrophic lateral sclerosis

Davood Fathi; Shahriar Nafissi; Shahram Attarian; Christoph Neuwirth; Farzad Fatehi

An overview of motor unit number index reproducibility in amyotrophic lateral sclerosis

Iran J Neurol. 2019 Jul 6;18(3):119-126.

Authors

Davood Fathi^{1

2}, Shahriar Nafissi¹, Shahram Attarian³, Christoph Neuwirth⁴, Farzad Fatehi^{1

5}

Affiliations

¹ Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
² Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
³ Reference Centre for Neuromuscular Disorders and ALS, CHU La Timone, Aix-Marseille University, Marseille, France.
⁴ Neuromuscular Disease Unit/ALS Clinic, Kantonspital St. Gallen, St. Gallen, Switzerland.
⁵ Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 31749933
PMCID: PMC6858602

Abstract

Motor unit number index (MUNIX) is an electrophysiological technique to give an estimate of functioning motor neurons in a muscle. For any given neurophysiological technique for the use in clinical or research studies, reproducibility between different operators and in a single operator in different times is one of the most important qualities, which must be evaluated and approved by different examiners and centers. After its introduction, testing the reproducibility of MUNIX was the aim of many studies to show this quality of the technique. In this review, we aimed to summarize all the studies, which have been performed up to now to approve MUNIX reproducibility in amyotrophic lateral sclerosis comparing healthy individuals.

Keywords: Amyotrophic Lateral Sclerosis; Motor Unit Number Index; Reproducibility of Results.

Publication types

Review