Noninvasive Detection and Localization of Genitourinary Cancers Using Urinary Sediment DNA Methylomes and Copy Number Profiles

Zhengzheng Xu; Guangzhe Ge; Bao Guan; Zhentao Lei; Xueyu Hao; Yuanyuan Zhou; Yue Shi; Huan Lu; Jilu Wang; Ding Peng; XiKang Wu; Huiying He; Bao Zhang; Xuesong Li; Liqun Zhou; Weimin Ci

doi:10.1016/j.eururo.2019.11.006

Noninvasive Detection and Localization of Genitourinary Cancers Using Urinary Sediment DNA Methylomes and Copy Number Profiles

Eur Urol. 2020 Feb;77(2):288-290. doi: 10.1016/j.eururo.2019.11.006. Epub 2019 Nov 17.

Authors

Zhengzheng Xu¹, Guangzhe Ge¹, Bao Guan², Zhentao Lei³, Xueyu Hao¹, Yuanyuan Zhou⁴, Yue Shi⁴, Huan Lu¹, Jilu Wang¹, Ding Peng², XiKang Wu⁵, Huiying He⁵, Bao Zhang³, Xuesong Li⁶, Liqun Zhou⁷, Weimin Ci⁸

Affiliations

¹ Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics,Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
² Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics,Chinese Academy of Sciences, Beijing, China; Department of Urology, Peking University First Hospital, Beijing, China; Institute of Urology, Peking University, Beijing, China; National Urological Cancer Center, Beijing, China.
³ Department of Urology, Beijing Aerospace Center Hospital, Beijing, China.
⁴ Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics,Chinese Academy of Sciences, Beijing, China.
⁵ Department of Pathology, School of Basic Medical Sciences, Third Hospital, Peking University Health Science Center, Beijing, China.
⁶ Department of Urology, Peking University First Hospital, Beijing, China; Institute of Urology, Peking University, Beijing, China; National Urological Cancer Center, Beijing, China.
⁷ Department of Urology, Peking University First Hospital, Beijing, China; Institute of Urology, Peking University, Beijing, China; National Urological Cancer Center, Beijing, China. Electronic address: zhoulqmail@sina.com.
⁸ Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics,Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China; Institute of Stem Cell Regeneration, Chinese Academy of Sciences, Beijing, China. Electronic address: ciwm@big.ac.cn.

PMID: 31744643
DOI: 10.1016/j.eururo.2019.11.006

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

DNA Copy Number Variations*
Epigenome*
Humans
Urinalysis
Urogenital Neoplasms / diagnosis*
Urogenital Neoplasms / genetics*
Urogenital Neoplasms / urine