Travelling Together: A Unifying Pathomechanism for ALS

Pietro Fratta; Nicol Birsa; Andrew P Tosolini; Giampietro Schiavo

doi:10.1016/j.tins.2019.10.006

Travelling Together: A Unifying Pathomechanism for ALS

Trends Neurosci. 2020 Jan;43(1):1-2. doi: 10.1016/j.tins.2019.10.006. Epub 2019 Nov 16.

Authors

Pietro Fratta¹, Nicol Birsa², Andrew P Tosolini³, Giampietro Schiavo⁴

Affiliations

¹ Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK. Electronic address: p.fratta@ucl.ac.uk.
² Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK; UK Dementia Research Institute, University College London, London WC1E 6BT, UK.
³ Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
⁴ Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK; UK Dementia Research Institute, University College London, London WC1E 6BT, UK; Discoveries Centre for Regenerative and Precision Medicine, University College London Campus, London WC1N 3BG, UK. Electronic address: giampietro.schiavo@ucl.ac.uk.

PMID: 31744630
DOI: 10.1016/j.tins.2019.10.006

Abstract

Axonal transport is critical for neuronal homeostasis and relies on motor complexes bound to cargoes via specific adaptors. However, the mechanisms responsible for the spatiotemporal regulation of axonal transport are not completely understood. A recent study by Liao et al. contributes to filling this gap by reporting that RNA granules 'hitchhike' on LAMP1-positive organelles using annexin A11 as a tether.

Keywords: LAMP1-positive organelles; RNA granules; amyotrophic lateral sclerosis; annexin A11; axonal transport.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Amyotrophic Lateral Sclerosis*
Annexins* / metabolism
Axonal Transport
Humans
Lysosomes / metabolism
Organelles
RNA

Travelling Together: A Unifying Pathomechanism for ALS

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