Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer's Disease

Federica Cioffi; Rayan Hassan Ibrahim Adam; Kerensa Broersen

doi:10.3233/JAD-190863

Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer's Disease

J Alzheimers Dis. 2019;72(4):981-1017. doi: 10.3233/JAD-190863.

Authors

Federica Cioffi¹, Rayan Hassan Ibrahim Adam¹, Kerensa Broersen²

Affiliations

¹ Nanobiophysics Group, Technical Medical Centre, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands.
² Applied Stem Cell Technologies, Technical Medical Centre, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands.

Abstract

Alzheimer's disease is the most common neurodegenerative disorder that can cause dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress which interconnects with other processes such as amyloid-β deposition, tau hyperphosphorylation, and tangle formation. This review discusses current thoughts on molecular mechanisms that may relate oxidative stress to Alzheimer's disease and identifies genetic factors observed from in vitro, in vivo, and clinical studies that may be associated with Alzheimer's disease-related oxidative stress.

Keywords: Alzheimer’s disease; amyloid-β; genetic factors; neurodegeneration; oxidative stress; reactive oxygen species; tau.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alzheimer Disease / metabolism*
Amyloid beta-Peptides / metabolism
Animals
Brain / metabolism*
Humans
Oxidative Stress / genetics*
Reactive Oxygen Species / metabolism*
tau Proteins / metabolism

Substances

Amyloid beta-Peptides
Reactive Oxygen Species
tau Proteins