N-WASP Guides Cancer Cells toward LPA

Klemens Rottner; Matthias Schaks

doi:10.1016/j.devcel.2019.10.029

N-WASP Guides Cancer Cells toward LPA

Dev Cell. 2019 Nov 18;51(4):415-417. doi: 10.1016/j.devcel.2019.10.029.

Authors

Klemens Rottner¹, Matthias Schaks²

Affiliations

¹ Division of Molecular Cell Biology, Zoological Institute, Technische Universität Braunschweig, Spielmannstrasse 7, 38106 Braunschweig, Germany; Department of Cell Biology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany; Braunschweig Integrated Centre of Systems Biology (BRICS), Rebenring 56, 38106 Braunschweig, Germany. Electronic address: k.rottner@tu-braunschweig.de.
² Division of Molecular Cell Biology, Zoological Institute, Technische Universität Braunschweig, Spielmannstrasse 7, 38106 Braunschweig, Germany; Department of Cell Biology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany.

PMID: 31743660
DOI: 10.1016/j.devcel.2019.10.029

Abstract

The actin remodeling factor N-WASP is best known as an Arp2/3 complex activator in processes like endocytosis, extracellular matrix degradation, and host-pathogen interaction. In this issue of Developmental Cell, Juin et al. establish a novel trafficking function for N-WASP in driving lysophosphatidic acid-dependent chemotaxis and metastasis of pancreatic cancer cells.

Publication types

Comment

MeSH terms

Actin-Related Protein 2-3 Complex
Actins
Cell Movement
Endocytosis
Humans
Pancreatic Neoplasms*
Receptors, Lysophosphatidic Acid
Wiskott-Aldrich Syndrome Protein, Neuronal*

Substances

Actin-Related Protein 2-3 Complex
Actins
LPAR1 protein, human
Receptors, Lysophosphatidic Acid
Wiskott-Aldrich Syndrome Protein, Neuronal