Zika Virus IgM 25 Months after Symptom Onset, Miami-Dade County, Florida, USA

Emerg Infect Dis. 2019 Dec;25(12):2264-2265. doi: 10.3201/eid2512.191022.

Abstract

We assessed IgM detection in Zika patients from the 2016 outbreak in Miami-Dade County, Florida, USA. Of those with positive or equivocal IgM after 12-19 months, 87% (26/30) had IgM 6 months later. In a survival analysis, ≈76% had IgM at 25 months. Zika virus IgM persists for years, complicating serologic diagnosis.

Keywords: Florida; IgM; IgM antibody capture ELISA; MAC-ELISA; Miami-Dade County; United States; Zika virus; antibody persistence; antibody survival; flaviviruses; immunoglobulin M; mosquitoborne viruses; vector-borne infections; viruses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antibodies, Viral / blood
  • Antibodies, Viral / immunology*
  • Disease Outbreaks
  • Female
  • Florida / epidemiology
  • Humans
  • Immunoglobulin M / blood
  • Immunoglobulin M / immunology*
  • Male
  • Middle Aged
  • Time Factors
  • Young Adult
  • Zika Virus / genetics
  • Zika Virus / immunology*
  • Zika Virus Infection / diagnosis
  • Zika Virus Infection / epidemiology*
  • Zika Virus Infection / immunology*
  • Zika Virus Infection / virology

Substances

  • Antibodies, Viral
  • Immunoglobulin M