Mandibular Osteonecrosis Associated with Antacid Therapy (Esomeprazole)

Simone Marconcini; Enrica Giammarinaro; Saverio Cosola; Anna Maria Genovesi; Ugo Covani

doi:10.12890/2019_001279

Mandibular Osteonecrosis Associated with Antacid Therapy (Esomeprazole)

Eur J Case Rep Intern Med. 2019 Oct 14;6(10):001279. doi: 10.12890/2019_001279. eCollection 2019.

Authors

Simone Marconcini¹, Enrica Giammarinaro¹, Saverio Cosola¹, Anna Maria Genovesi¹, Ugo Covani¹

Affiliation

¹ Tuscan Stomatologic Institute, Versilia General Hospital, Lido di Camaiore, Italy.

Abstract

Introduction: Osteonecrosis of the jaw has been consistently reported in the literature associated to the high-dose intravenous bisphosphonate therapy. However, osteonecrosis can also occur in patients who have other risk factors.

Case description: An unusual case of ONJ in a patient being treated with esomeprazole is reported.

Discussion: The probable association between proton pump inhibitor intake and osteonecrosis of the jaw should alert clinicians. Collaborations between medical and dental doctor and an early diagnosis might prevent or reduce the morbidity resulting from advanced destructive lesions of the jaw bone.

Learning points: Osteonecrosis of the jaw (ONJ) can occur in patients treated with bisphosphonates and corticosteroids and is associated with oral surgical procedures involving bone.Antacid drugs commonly used to treat gastro-oesophageal reflux could affect bone metabolism although no cases of ONJ in patients using proton pump inhibitors have been reported.Medical and dental practitioners should collaborate to prevent ONJ, identify previously unreported drug interactions, and treat patients in a more comprehensive manner.

Keywords: Mandibular osteonecrosis; antacid therapy; esomeprazole; osteonecrosis of the jaw; proton pump inhibitors.