Effect of Surfagon on Open Field and Elevated Plus Maze Behavior of Gonadectomized and Non-Gonadectomized Male Rats

O O Masalova; S B Kazakova; T N Savateeva-Lyubimova; K V Sivak; N S Sapronov; P D Shabanov

doi:10.1007/s10517-019-04644-4

Effect of Surfagon on Open Field and Elevated Plus Maze Behavior of Gonadectomized and Non-Gonadectomized Male Rats

Bull Exp Biol Med. 2019 Nov;168(1):52-54. doi: 10.1007/s10517-019-04644-4. Epub 2019 Nov 19.

Authors

O O Masalova¹, S B Kazakova², T N Savateeva-Lyubimova², K V Sivak², N S Sapronov³, P D Shabanov³

Affiliations

¹ Institute of Experimental Medicine, Ministry of Health of the Russian Federation, St. Petersburg, Russia. o.o.masalova@gmail.com.
² Research Institute of Influenza, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
³ Institute of Experimental Medicine, Ministry of Health of the Russian Federation, St. Petersburg, Russia.

PMID: 31741247
DOI: 10.1007/s10517-019-04644-4

Abstract

We studied the effect of gonadotropin-releasing hormone agonist surfagon (2 μg/kg, once, intraperitoneally) on anxious behavior of adult gonadectomized and non-gonadectomized male rats. It was shown that surfagon significantly increased anxiety of both gonadectomized and non-gonadectomized rats in the open-field test and in elevated plus maze.

Keywords: follicle-stimulating; gonadotropin-releasing hormone; hormone; testosterone; anxiety; luteinizing hormone.

MeSH terms

Animals
Anxiety / metabolism
Behavior, Animal / drug effects
Follicle Stimulating Hormone / metabolism
Gonadotropin-Releasing Hormone / analogs & derivatives*
Gonadotropin-Releasing Hormone / metabolism
Gonadotropin-Releasing Hormone / pharmacology
Luteinizing Hormone / metabolism
Male
Rats
Testosterone / metabolism

Substances

Gonadotropin-Releasing Hormone
Testosterone
surfagon
Luteinizing Hormone
Follicle Stimulating Hormone