Parechovirus A Pathogenesis and the Enigma of Genotype A-3

Adithya Sridhar; Eveliina Karelehto; Lieke Brouwer; Dasja Pajkrt; Katja C Wolthers

doi:10.3390/v11111062

Parechovirus A Pathogenesis and the Enigma of Genotype A-3

Viruses. 2019 Nov 14;11(11):1062. doi: 10.3390/v11111062.

Authors

Adithya Sridhar¹, Eveliina Karelehto¹, Lieke Brouwer¹, Dasja Pajkrt², Katja C Wolthers¹

Affiliations

¹ Laboratory of Clinical Virology, Department of Medical Microbiology, Amsterdam UMC, location Academic Medical Center, University of Amsterdam, 1100 AZ Amsterdam, The Netherlands.
² Department of Pediatrics, Emma Children's Hospital, Amsterdam UMC, location Academic Medical Center, University of Amsterdam, 1100 AZ Amsterdam, The Netherlands.

Abstract

ParechovirusA is a species in the Parechovirus genus within the Picornaviridae family that can cause severe disease in children. Relatively little is known on ParechovirusA epidemiology and pathogenesis. This review aims to explore the ParechovirusA literature and highlight the differences between ParechovirusA genotypes from a pathogenesis standpoint. In particular, the curious case of Parechovirus-A3 and the genotype-specific disease association will be discussed. Finally, a brief outlook on ParechovirusA research is provided.

Keywords: parechovirus; parechovirus A; parechovirus A-3; pathogenesis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Disease Management
Disease Susceptibility*
Evolution, Molecular
Genome, Viral
Genomics / methods
Genotype*
Host-Pathogen Interactions*
Humans
Life Cycle Stages
Parechovirus / classification*
Parechovirus / genetics*
Parechovirus / growth & development
Picornaviridae Infections / epidemiology
Picornaviridae Infections / therapy
Picornaviridae Infections / virology*