Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of Macaranga tanarius

Thi Mai Huong Doan; Thuy Linh Nguyen; Thi Thanh Van Trinh; Van Nam Vu; Thi Dao Phi; Marc Litaudon; Fanny Roussi; Van Minh Chau; Van Cuong Pham

doi:10.1155/2019/2917032

Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of Macaranga tanarius

J Anal Methods Chem. 2019 Oct 13:2019:2917032. doi: 10.1155/2019/2917032. eCollection 2019.

Authors

Affiliations

¹ Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
² Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
³ Institut de Chimie des Substances Naturelles, CNRS, ICSN UPR2301, University of Paris-Saclay, 91198 Gif-sur-Yvette, France.

Abstract

A new flavonoid, macatanarin D (1), together with five known stilbenes (2-6), was isolated from fruit glandular trichomes of Macaranga tanarius. Their structures were elucidated on the basis of spectroscopic methods and through comparison with data reported in the literature. All isolated compounds were evaluated for their cytotoxic activities against KB and MCF-7 cell lines. Compounds 3, 4, and 5 showed the strongest activities against both cell lines with IC₅₀ values in the range of 0.03-0.12 μM, and compound 2 only showed a significant cytotoxicity against KB cell line (IC₅₀ = 0.26 μM) and a moderate cytotoxicity against MCF-7 (IC₅₀ = 10.4 μM). Compounds 1 and 6 showed weak cytotoxic activities against KB cell line with IC₅₀ values of 29.3 and 24.7 μM, respectively.

Grants and funding

D43 TW010530/TW/FIC NIH HHS/United States