T serotyping of group a streptococcus isolated from patients with pharyngitis or streptococcal toxic shock syndrome in Japan between 2005 and 2017

Tadayoshi Ikebe; Rumi Okuno; Yumi Uchitani; Yoshiko Kanda; Mari Sasaki; Kaoru Uchida; Kazuki Chiba; Takahiro Yamaguchi; Hitoshi Otsuka; Miyuki Suzuki; Hitomi Ohya; Haruo Watanabe; Makoto Ohnishi; Working Group for Beta-Hemolytic Streptococci in Japan

doi:10.1016/j.jiac.2019.10.010

T serotyping of group a streptococcus isolated from patients with pharyngitis or streptococcal toxic shock syndrome in Japan between 2005 and 2017

J Infect Chemother. 2020 Feb;26(2):157-161. doi: 10.1016/j.jiac.2019.10.010. Epub 2019 Nov 15.

Collaborators

Working Group for Beta-Hemolytic Streptococci in Japan:
Yo Morimoto¹⁰, Keiko Ogawa¹⁰, Takayuki Konno¹¹, Kaori Iwabuchi¹², Junji Seto¹³, Toshinobu Hoshi¹⁴, Yuki Kimura¹⁵, Ryouko Kikuchi¹⁶, Kazunari Yamamoto¹⁶, Miki Nagata¹⁷, Keiji Funatogawa¹⁸, Akira Wakatsuki¹⁹, Tomoe Sao¹⁹, Hajime Kurosawa²⁰, Kazunori Kishida²¹, Kentaro Tomari²², Yuko Matsumoto²³, Eiko Yuzawa²⁴, Fumiko Saka²⁵, Takaya Yamagami²⁶, Yukiko Igawa²⁷, Takayuki Shiomoto²⁸, Yusuke Sato²⁹, Shuntaro Umeda³⁰, Shinichiro Shibata³⁰, Makiko Noda³¹, Yukiko Kadokura³¹, Chikara Nakagawa³², Megumi Okada³³, Hirotoshi Iwasawa³⁴, Yumi Akiyama³⁵, Noriko Nakanishi³⁶, Ryutaro Murayama³⁷, Masaki Hiragakiuchi³⁷, Takako Yoshida³⁸, Kayoko Nakaoka³⁹, Sakura Iwashita³⁹, Yuko Kiguchi⁴⁰, Kouji Takeuchi⁴¹, Jun Kawase⁴², Hideaki Kariya⁴³, Takahiro Hiratsuka⁴⁴, Hiroko Akita⁴⁴, Kaori Sato⁴⁵, Youko Iwashita⁴⁶, Go Sato⁴⁷, Aya Shinohara⁴⁷, Yuki Abe⁴⁸, Tae Taniwaki⁴⁹, Midori Kimura⁵⁰, Masato Miyahira⁵¹, Tetsuya Kakita⁵¹

Affiliations

¹ Department of Bacteriology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan. Electronic address: tdikebe@nih.go.jp.
² Department of Microbiology, Tokyo Metropolitan Institute of Public Health, 3-24-1 Hyakunin-cho, Shinjuku-ku, Tokyo, 169-0073, Japan.
³ Laboratory of Microbiology, Oita Prefectural Institute of Health and Environment, 2-8 Takae-Nishi, Oita, 870-1117, Japan.
⁴ Department of Bacteriology, Toyama Institute of Health, 17-1 Naka-Taikouyama, Imizu, Toyama, 939-0363, Japan.
⁵ Department of Microbiology, Fukushima Prefectural Institute of Public Health, 16-6 Mitouchi, Hokida, Fukushima, 960-8560, Japan.
⁶ Division of Microbiology, Osaka Institute of Public Health, 1-3-69 Nakamichi, Higashinari-ku, Osaka, 537-0025, Japan.
⁷ Department of Public Health Sciences, Yamaguchi Prefectural Institute of Public Health and Environment, 2-5-67 Aoi, Yamaguchi 753-0821, Japan.
⁸ Division of Microbiology, Kanagawa Prefectural Institute of Public Health, 1-3-1 Shimomachiya, Chigasaki, Kanagawa, 253-0087, Japan.
⁹ Department of Bacteriology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
¹⁰ Hokkaido Institute of Public Health, Japan.
¹¹ Akita Prefectural Research Center for Public Health and Environment, Japan.
¹² Iwate Prefectural Research Institute for Environmental Sciences and Public Health, Japan.
¹³ Yamagata Prefectural Institute of Public Health, Japan.
¹⁴ Sendai City Institute of Public Health, Japan.
¹⁵ Niigata Prefectural Institute of Public Health and Environmental Sciences, Japan.
¹⁶ Niigata City Institute of Public Health and Environment, Japan.
¹⁷ Ibaraki Prefectural Institute of Public Health, Japan.
¹⁸ Tochigi Prefectural Institute of Public Health and Environmental Science, Japan.
¹⁹ Utsunomiya City Institute of Public Health and Environment Science, Japan.
²⁰ Gunma Prefectural Institute of Public Health and Environmental Sciences, Japan.
²¹ Chiba Prefectural Chuo Meat Sanitary Inspection Station, Japan.
²² Saitama City Institute of Health Science and Research, Saitama Prefectural Institute of Public Health, Japan.
²³ Yokohama City Institute of Public Health, Japan.
²⁴ Kawasaki City Institute for Public Health, Japan.
²⁵ Sagamihara City Institute of Public Health, Japan.
²⁶ Yamanashi Institute of Public Health and Environment, Japan.
²⁷ Nagano Environmental Conservation Research Institute, Japan.
²⁸ Ishikawa Prefectural Institute of Public Health and Environmental Science, Japan.
²⁹ Gifu Municipal Institute of Public Health, Japan.
³⁰ Nagoya City Public Health Research Institute, Japan.
³¹ Gifu Prefectural Research Institute for Health and Environmental Sciences, Japan.
³² Kyoto City Institute of Health and Environmental Science, Japan.
³³ Osaka City Health Center, Japan.
³⁴ Sakai City Public Health Department, Japan.
³⁵ Hyogo Prefectural Institute of Public Health Science, Japan.
³⁶ Kobe Institute of Health, Japan.
³⁷ Amagasaki City Institute of Public Health, Japan.
³⁸ Nara Prefecture Institute of Health, Japan.
³⁹ Wakayama Prefectural Research Center of Environment and Public Health, Japan.
⁴⁰ Wakayama City Institute of Public Health, Japan.
⁴¹ Tottori Prefectural Institute of Public Health and Environment, Japan.
⁴² Shimane Prefectural Institute of Public Health and Environmental Science, Japan.
⁴³ Okayama Prefectural Institute for Environmental Science and Public Health, Japan.
⁴⁴ Hiroshima Prefectural Technology Research Institute, Japan.
⁴⁵ Hiroshima City Institute of Public Health, Japan.
⁴⁶ Kagawa Prefectural Research Institute for Environmental Science and Public Health, Japan.
⁴⁷ Tokushima Prefectural Public Health Pharmaceutical and Environmental Sciences Center, Japan.
⁴⁸ Ehime Prefectural Institute of Public Health and Environmental Science, Japan.
⁴⁹ Kochi Prefectural Public Health and Environmental Science Research Institute, Japan.
⁵⁰ Saga Prefectural Institute of Public Health and Pharmaceutical Research, Japan.
⁵¹ Okinawa Prefectural Institute of Health and Environment, Japan.

PMID: 31735631
DOI: 10.1016/j.jiac.2019.10.010

Abstract

Streptococcus pyogenes (group A streptococcus; GAS) is an important gram-positive human pathogen capable of causing diseases ranging from mild superficial skin and pharyngeal infections to more severe invasive diseases, including streptococcal toxic shock syndrome (STSS). GAS produces a T protein, and T serotyping has considerable discriminatory power for epidemiological characterization of GAS. To clarify the relationship between STSS and pharyngitis in Japan, we examined the T serotypes of GAS strains isolated from clinical specimens of streptococcal infections (STSS, 951 isolates; pharyngitis, 16268 isolates) from 2005 to 2017. The most prevalent T serotype from pharyngitis isolates was T12, followed by T1, T4, and TB3264. The most prevalent T serotype from STSS isolates was T1, followed by TB3264. Trend of increase and decrease in the frequency of T1 or TB3264 isolation from pharyngitis was correlated with that of STSS patients. The increase of T1 or TB3264 strain-infection in pharyngitis patients may increase the probability of causing STSS, indicating that careful monitoring of GAS serotypes is essential for the prediction of rapid increase of STSS in time to develop effective management strategies.

Keywords: Group a streptococcus; Pharyngitis; Streptococcal toxic shock syndrome; T serotype.

MeSH terms

Humans
Japan
Pharyngitis / epidemiology
Pharyngitis / microbiology*
Serotyping
Shock, Septic / epidemiology
Shock, Septic / microbiology*
Streptococcal Infections / epidemiology
Streptococcal Infections / microbiology*
Streptococcus pyogenes / classification*
Streptococcus pyogenes / isolation & purification*