Cancer and RASSF1A/RASSF1C, the Two Faces of Janus

Fatéméh Dubois; Emmanuel Bergot; Guénaëlle Levallet

doi:10.1016/j.trecan.2019.10.001

Cancer and RASSF1A/RASSF1C, the Two Faces of Janus

Trends Cancer. 2019 Nov;5(11):662-665. doi: 10.1016/j.trecan.2019.10.001. Epub 2019 Oct 28.

Authors

Fatéméh Dubois¹, Emmanuel Bergot², Guénaëlle Levallet³

Affiliations

¹ Normandie University, UNICAEN, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre national de la recherche scientifique (CNRS), Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT)/Cervoxy Group, Groupement d'intérêt publique (GIP) Cyceron, Caen, France; Department of Pathology, Centre Hospitalier Universitaire (CHU) de Caen, Caen, France.
² Normandie University, UNICAEN, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre national de la recherche scientifique (CNRS), Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT)/Cervoxy Group, Groupement d'intérêt publique (GIP) Cyceron, Caen, France; Department of Pulmonology and Thoracic Oncology, Centre Hospitalier Universitaire (CHU) de Caen, Caen, France.
³ Normandie University, UNICAEN, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre national de la recherche scientifique (CNRS), Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT)/Cervoxy Group, Groupement d'intérêt publique (GIP) Cyceron, Caen, France; Department of Pathology, Centre Hospitalier Universitaire (CHU) de Caen, Caen, France. Electronic address: guenaelle.levallet@unicaen.fr.

PMID: 31735284
DOI: 10.1016/j.trecan.2019.10.001

Abstract

Although encoded by the same gene, RASSF1A and RASSF1C are two opposites in carcinogenesis; one is a tumor suppressor that is silenced in a plethora of cancers, while the other is an oncogene that remains unaffected. Here, we aim to understand why and to highlight their respective clinical implications.

Keywords: C1 domain; RASSF1A; RASSF1C; carcinogenesis; cell homeostasis.

MeSH terms

Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor*
Humans
Neoplasms / genetics*
Oncogenes / genetics*
Protein Isoforms / chemistry
Protein Isoforms / genetics
Protein Isoforms / metabolism
Tumor Suppressor Proteins / chemistry
Tumor Suppressor Proteins / genetics*
Tumor Suppressor Proteins / metabolism

Substances

Protein Isoforms
RASSF1 protein, human
Tumor Suppressor Proteins