YAP1-fusions in pediatric NF2-wildtype meningioma

Philipp Sievers; Jason Chiang; Daniel Schrimpf; Damian Stichel; Nagarajan Paramasivam; Martin Sill; Tenzin Gayden; Belen Casalini; David E Reuss; James Dalton; Kristian W Pajtler; Daniel Hänggi; Christel Herold-Mende; Elisabeth Rushing; Andrey Korshunov; Christian Mawrin; Michael Weller; Matthias Schlesner; Wolfgang Wick; Nada Jabado; David T W Jones; Stefan M Pfister; Andreas von Deimling; David W Ellison; Felix Sahm

doi:10.1007/s00401-019-02095-9

YAP1-fusions in pediatric NF2-wildtype meningioma

Acta Neuropathol. 2020 Jan;139(1):215-218. doi: 10.1007/s00401-019-02095-9. Epub 2019 Nov 16.

Authors

Philipp Sievers^{1

2}, Jason Chiang³, Daniel Schrimpf^{1

2}, Damian Stichel^{1

2}, Nagarajan Paramasivam⁴, Martin Sill^{5

6}, Tenzin Gayden^{7

8

9}, Belen Casalini^{1

2}, David E Reuss^{1

2}, James Dalton³, Kristian W Pajtler^{5

6

10}, Daniel Hänggi¹¹, Christel Herold-Mende¹², Elisabeth Rushing¹³, Andrey Korshunov^{1

2

5}, Christian Mawrin¹⁴, Michael Weller¹⁵, Matthias Schlesner⁴, Wolfgang Wick^{16

17}, Nada Jabado^{7

8

9}, David T W Jones^{5

18}, Stefan M Pfister^{5

6

10}, Andreas von Deimling^{1

2}, David W Ellison³, Felix Sahm^{19

20

21}

Affiliations

¹ Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
² Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
³ Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
⁴ Bioinformatics and Omics Data Analytics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁵ Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
⁶ Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁷ Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.
⁸ Department of Pediatrics, McGill University, Montreal, QC, H4A 3J1, Canada.
⁹ The Research Institute of the McGill University Health Center, Montreal, QC, H4A 3J1, Canada.
¹⁰ Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.
¹¹ Department of Neurosurgery, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany.
¹² Division of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
¹³ Institute of Neuropathology, University Hospital and University of Zurich, Zurich, Switzerland.
¹⁴ Institute of Neuropathology, Otto-von-Guericke University, Magdeburg, Germany.
¹⁵ Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.
¹⁶ Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁷ Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.
¹⁸ Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁹ Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. felix.sahm@med.uni-heidelberg.de.
²⁰ Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. felix.sahm@med.uni-heidelberg.de.
²¹ Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. felix.sahm@med.uni-heidelberg.de.

PMID: 31734728
DOI: 10.1007/s00401-019-02095-9

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adaptor Proteins, Signal Transducing / genetics*
Adolescent
Adult
Child
Child, Preschool
Female
Genes, Neurofibromatosis 2
Humans
Infant
Male
Meningeal Neoplasms / genetics*
Meningioma / genetics*
Oncogene Fusion / genetics
Oncogene Proteins, Fusion / genetics
Transcription Factors / genetics*
YAP-Signaling Proteins

Substances

Adaptor Proteins, Signal Transducing
Oncogene Proteins, Fusion
Transcription Factors
YAP-Signaling Proteins
YAP1 protein, human

Publication types

MeSH terms

Substances

Grants and funding