Control of Lymphocyte Fate, Infection, and Tumor Immunity by TCF-1

Trends Immunol. 2019 Dec;40(12):1149-1162. doi: 10.1016/j.it.2019.10.006. Epub 2019 Nov 14.

Abstract

T cell factor-1 (TCF-1), encoded by Tcf7, is a transcription factor and histone deacetylase (HDAC) essential for commitment to both the T cell and the innate lymphoid cell (ILC) lineages in mammals. In this review, we discuss the multifunctional role of TCF-1 in establishing these lineages and the requirement for TCF-1 throughout lineage differentiation and maintenance of lineage stability. We highlight recent reports showing promise for TCF-1 as a novel biomarker to identify recently characterized subsets of exhausted CD8+ T cells that may help to predict patient responses to immune checkpoint blockade (ICB).

Keywords: T cell; T cell factor-1; TCF-1; immunotherapy; innate lymphoid cell; stem cell-like memory; transcription factor.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • CD8-Positive T-Lymphocytes / physiology*
  • Cell Differentiation
  • Disease Resistance
  • Gene Expression Regulation
  • Humans
  • Immunity / genetics*
  • Mice
  • Neoplasms / immunology*
  • T Cell Transcription Factor 1 / genetics
  • T Cell Transcription Factor 1 / metabolism*
  • Virus Diseases / immunology*

Substances

  • T Cell Transcription Factor 1