The Kidney Biopsy in Systemic Lupus Erythematosus: A View of the Past and a Vision of the Future

Isabelle Ayoub; Clarissa Cassol; Salem Almaani; Brad Rovin; Samir V Parikh

doi:10.1053/j.ackd.2019.08.015

The Kidney Biopsy in Systemic Lupus Erythematosus: A View of the Past and a Vision of the Future

Adv Chronic Kidney Dis. 2019 Sep;26(5):360-368. doi: 10.1053/j.ackd.2019.08.015.

Authors

Isabelle Ayoub¹, Clarissa Cassol², Salem Almaani³, Brad Rovin³, Samir V Parikh³

Affiliations

¹ Department of Internal Medicine, Division of Nephrology, The Ohio State University Wexner Medical Center, Columbus, OH. Electronic address: Isabelle.ayoub@osumc.edu.
² Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH.
³ Department of Internal Medicine, Division of Nephrology, The Ohio State University Wexner Medical Center, Columbus, OH.

PMID: 31733720
DOI: 10.1053/j.ackd.2019.08.015

Abstract

The kidney biopsy advanced our understanding of kidney disease in systemic lupus erythematosus. It allowed for better recognition and classification of lupus nephritis (LN). Several LN classifications have been devised in an effort to inform treatment decision and predict prognosis, and these are being further updated. In this review, we will examine the role of diagnostic as well as repeat kidney biopsy in the management of LN, including the potential role of molecular interrogation as a step forward beyond conventional histology to guide the discovery of novel biomarkers and a precision medicine approach to the management of LN.

Keywords: Histology; Kidney biopsy; Lupus nephritis; Molecular pathology; Systemic lupus erythematosus.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biopsy / trends*
Humans
Kidney / pathology*
Lupus Erythematosus, Systemic* / complications
Lupus Erythematosus, Systemic* / pathology
Lupus Nephritis* / classification
Lupus Nephritis* / diagnosis
Pathology, Molecular / methods*
Prognosis