Do HCN4 Variants Predispose to Thoracic Aortic Aneurysms and Dissections?

Circ Genom Precis Med. 2019 Dec;12(12):e002626. doi: 10.1161/CIRCGEN.119.002626. Epub 2019 Nov 15.

Authors

Hannah L Hanania^{1

2}, Ellen S Regalado¹, Dong-Chuan Guo¹, Lili Xu¹, Erin Demo³, Denver Sallee³, Dianna M Milewicz¹

Affiliations

¹ Division of Medical Genetics, Department of Internal Medicine, The University of Texas Health Science Center (H.L.H., E.S.R., D.-c.G., L.X., D.M.M.).
² Program in Biochemistry and Cell Biology, Rice University, Houston, TX (H.L.H.).
³ Pediatric Cardiology Division, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA (E.D., D.S.).

PMID: 31731876
DOI: 10.1161/CIRCGEN.119.002626

No abstract available

Keywords: aneurysm; aortic diseases; bradycardia; genetic testing; hypertrophy.

Publication types

Letter
Research Support, N.I.H., Extramural
Comment

MeSH terms

Aortic Aneurysm, Thoracic*
Aortic Dissection*
Cardiomyopathies*
Humans
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Muscle Proteins
Pedigree
Potassium Channels

Substances

HCN4 protein, human
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Muscle Proteins
Potassium Channels

Grants and funding

R01 HL109942/HL/NHLBI NIH HHS/United States