Current Research and Use of Mesenchymal Stem Cells in the Therapy of Autoimmune Diseases

Youdong Chen; Qian Yu; Yifan Hu; Yuling Shi

doi:10.2174/1574888X14666190429141421

Current Research and Use of Mesenchymal Stem Cells in the Therapy of Autoimmune Diseases

Curr Stem Cell Res Ther. 2019;14(7):579-582. doi: 10.2174/1574888X14666190429141421.

Authors

Youdong Chen^{1

2}, Qian Yu^{1

2}, Yifan Hu^{1

2}, Yuling Shi^{1

2}

Affiliations

¹ Department of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.
² Institute of Psoriasis, Tongji University School of Medicine, Shanghai 200072, China.

PMID: 31729289
DOI: 10.2174/1574888X14666190429141421

Abstract

Mesenchymal Stem Cells (MSCs) represent a heterogeneous group of self-renewal, multipotent non-hematopoietic stem cells, which display profound immunomodulatory functions and promising therapeutic effects. Autoimmune diseases, which result from an aberrant immune response to selfantigens, can be detrimental to nearly all body tissues. With the advance in developing a novel treatment, including biological agents, it is still impossible to cure autoimmune disorders. Recent studies demonstrate the remarkable therapeutic effectiveness of MSCs towards a wide array of autoimmune diseases. In this review, the immunomodulatory influence of MSCs over immune cells and the application of MSCs transplantation in treating autoimmune diseases are highlighted.

Keywords: IBD; Mesenchymal stem cell; RA; SLE; autoimmune diseases; cellular therapy; psoriasis; umbilical cord-derived MSC..

Publication types

Review

MeSH terms

Animals
Autoimmune Diseases / therapy*
Biomedical Research*
Cell Differentiation
Cell- and Tissue-Based Therapy / methods*
Humans
Mesenchymal Stem Cell Transplantation / methods*
Mesenchymal Stem Cells / cytology*