Update of inflammasome activation in microglia/macrophage in aging and aging-related disease

Meng-Yan Hu; Yin-Yao Lin; Bing-Jun Zhang; Dan-Li Lu; Zheng-Qi Lu; Wei Cai

doi:10.1111/cns.13262

Update of inflammasome activation in microglia/macrophage in aging and aging-related disease

CNS Neurosci Ther. 2019 Dec;25(12):1299-1307. doi: 10.1111/cns.13262. Epub 2019 Nov 14.

Authors

Meng-Yan Hu¹, Yin-Yao Lin¹, Bing-Jun Zhang¹, Dan-Li Lu¹, Zheng-Qi Lu¹, Wei Cai^{1

2}

Affiliations

¹ Department of Neurology, Center for Mental and Neurological Disorders and Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
² Center of Clinical Immunology, Center for Mental and Neurological Disorders and Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Abstract

Aging and aging-related CNS diseases are associated with inflammatory status. As an efficient amplifier of immune responses, inflammasome is activated and played detrimental role in aging and aging-related CNS diseases. Macrophage and microglia display robust inflammasome activation in infectious and sterile inflammation. This review discussed the impact of inflammasome activation in microglia/macrophage on senescence "inflammaging" and aging-related CNS diseases. The preventive or therapeutic effects of targeting inflammasome on retarding aging process or tackling aging-related diseases are also discussed.

Keywords: aging; inflammasome; inflammation; macrophage; microglia.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aging / pathology*
Animals
Central Nervous System Diseases / pathology*
Humans
Inflammasomes*
Inflammation
Macrophages / pathology*
Microglia / pathology*

Substances

Inflammasomes