Abstract
We report a supramolecular photo-responsive antibiotic (azobenzene-norfloxacin/αCD). This supramolecule exhibited a higher "on-off" ratio of antibacterial ability than azobenzene-norfloxacin alone under UV irradiation. It offers an approach to efficiently regulate the activity of antibiotics by combining the supramolecular and light-regulating strategies together.
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Azo Compounds / chemistry*
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Bacteria / drug effects
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Drug Resistance, Bacterial / drug effects
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Isomerism
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Norfloxacin / chemistry
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Norfloxacin / pharmacology
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Temperature
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Ultraviolet Rays
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beta-Cyclodextrins / chemistry*
Substances
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Anti-Bacterial Agents
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Azo Compounds
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beta-Cyclodextrins
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azobenzene
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Norfloxacin