Various CAM tumor models

Aoi Komatsu; Yuya Higashi; Kotaro Matsumoto

doi:10.1016/bs.enz.2019.10.001

Various CAM tumor models

Enzymes. 2019:46:37-57. doi: 10.1016/bs.enz.2019.10.001. Epub 2019 Oct 31.

Authors

Aoi Komatsu¹, Yuya Higashi¹, Kotaro Matsumoto²

Affiliations

¹ Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto, Japan.
² Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto, Japan. Electronic address: matsumoto.kotaro.5r@kyoto-u.ac.jp.

PMID: 31727276
DOI: 10.1016/bs.enz.2019.10.001

Abstract

Many types of in vivo animal tumor models have been established. Among these, the chicken chorioallantoic membrane (CAM) model has proven to be particularly useful for transplanting various types of cancer cell lines or tumor tissues to study tumor formation, angiogenesis and metastasis. The CAM model is useful as an animal tumor model, as tumor could be rapidly formed. The tumor formation occurs in 3-4 days, much faster than in mouse models. In addition, the CAM model can be used for drug screening for cancer therapy. This chapter provides an overview of various types of CAM tumor models.

Keywords: CAM tumor model; Drug screening; Patient tumor; Tumor development; Tumor tissue.

Publication types

Review

MeSH terms

Animals
Chick Embryo
Chorioallantoic Membrane / pathology*
Disease Models, Animal
Mice
Neoplasms / pathology*
Neovascularization, Pathologic