Under the revised demand of theoretic development in clinical practice and scientific research of acupuncture and moxibustion, the reconstruction of the theory was discussed on the "three yin and three yang" subarea division in the body and acupuncture effect in line with the traditional thinking of Chinese medicine so as to explore the longitudinal foundation and rule in the human body for the "effective stimulation". ①Based on the theory of "qi-space correlation" in Internal Classic and the source of nomenclature of "three yin and three yang", the body is divided in stereo zone in accordance with the theory of "three yin and three yang". ②In view of theoretical reasoning and practical interpretation, it is expounded that the same longitudinal stereo zone subarea in the body could respond to diseases and generate therapeutic effects. ③It is pointed out that the subareas of "three yin and three yang" in the body are closely related to meridians and collaterals, which is the basis of the spatial structure and and physical effect. The importance of the "body" itself is ignored nowadays because of the conventional thinking of "qi and blood" in traditional Chinese medicine.
Keywords: acupuncture effect; body subarea; qi-space correlation; three yin and three yang.