Abstract
We designed a tandem stimuli-responsive assembly based on a guanidinium-modified calix[5]arene (GC5A-6C) and eosin Y modified hyaluronic acid (EY-HA), which showed hyaluronidase-triggered disassembly and ATP-activated release of EY. Both hyaluronidase and ATP are tumor biomarkers, and therefore, the present system shows potential in precision delivery with respect to tumor phototheranostics.
MeSH terms
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Adenosine Triphosphate / chemistry
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Adenosine Triphosphate / metabolism*
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Biomarkers, Tumor / chemistry
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Biomarkers, Tumor / metabolism
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Calixarenes / chemistry
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Calixarenes / metabolism*
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Eosine Yellowish-(YS) / chemistry
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Eosine Yellowish-(YS) / metabolism*
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Guanidine / chemistry
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Guanidine / metabolism*
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Humans
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Hyaluronic Acid / chemistry
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Hyaluronic Acid / metabolism*
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Hyaluronoglucosaminidase / chemistry
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Hyaluronoglucosaminidase / metabolism*
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Macromolecular Substances / chemistry
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Macromolecular Substances / metabolism
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Polymers / chemistry
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Polymers / metabolism
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Theranostic Nanomedicine
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Tumor Microenvironment
Substances
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Biomarkers, Tumor
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Macromolecular Substances
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Polymers
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Calixarenes
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Adenosine Triphosphate
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Hyaluronic Acid
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Hyaluronoglucosaminidase
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Guanidine
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Eosine Yellowish-(YS)