A hyaluronidase/ATP tandem stimuli-responsive supramolecular assembly

Chem Commun (Camb). 2019 Nov 26;55(95):14387-14390. doi: 10.1039/c9cc08199b.

Abstract

We designed a tandem stimuli-responsive assembly based on a guanidinium-modified calix[5]arene (GC5A-6C) and eosin Y modified hyaluronic acid (EY-HA), which showed hyaluronidase-triggered disassembly and ATP-activated release of EY. Both hyaluronidase and ATP are tumor biomarkers, and therefore, the present system shows potential in precision delivery with respect to tumor phototheranostics.

MeSH terms

  • Adenosine Triphosphate / chemistry
  • Adenosine Triphosphate / metabolism*
  • Biomarkers, Tumor / chemistry
  • Biomarkers, Tumor / metabolism
  • Calixarenes / chemistry
  • Calixarenes / metabolism*
  • Eosine Yellowish-(YS) / chemistry
  • Eosine Yellowish-(YS) / metabolism*
  • Guanidine / chemistry
  • Guanidine / metabolism*
  • Humans
  • Hyaluronic Acid / chemistry
  • Hyaluronic Acid / metabolism*
  • Hyaluronoglucosaminidase / chemistry
  • Hyaluronoglucosaminidase / metabolism*
  • Macromolecular Substances / chemistry
  • Macromolecular Substances / metabolism
  • Polymers / chemistry
  • Polymers / metabolism
  • Theranostic Nanomedicine
  • Tumor Microenvironment

Substances

  • Biomarkers, Tumor
  • Macromolecular Substances
  • Polymers
  • Calixarenes
  • Adenosine Triphosphate
  • Hyaluronic Acid
  • Hyaluronoglucosaminidase
  • Guanidine
  • Eosine Yellowish-(YS)