A dataset on the effect of exercise-conditioned human sera in three-dimensional breast cancer cell culture

Mauro De Santi; Giulia Baldelli; Francesco Lucertini; Valentina Natalucci; Giorgio Brandi; Elena Barbieri

doi:10.1016/j.dib.2019.104704

A dataset on the effect of exercise-conditioned human sera in three-dimensional breast cancer cell culture

Data Brief. 2019 Oct 21:27:104704. doi: 10.1016/j.dib.2019.104704. eCollection 2019 Dec.

Authors

Mauro De Santi¹, Giulia Baldelli¹, Francesco Lucertini², Valentina Natalucci², Giorgio Brandi¹, Elena Barbieri^{2

3}

Affiliations

¹ Biomolecular Sciences Department, Pharmacology and Public Health Unit, University of Urbino Carlo Bo, Italy.
² Biomolecular Sciences Department, Exercise and Health Sciences Unit, University of Urbino Carlo Bo, Italy.
³ Interuniversity Institute of Myology, Urbino, Italy.

Abstract

Epidemiological evidence shows that physical activity lowers the risk of developing breast cancer and decreases the risk of disease recurrence [1,2]. The main hypothesis on the positive effects of exercise-oncology has focused on lowering the basal systemic levels of cancer risk factors with exercise training. Recently, the effects of cancer progression control by components released after acute exercise bouts have gained attention [3,4]. However, the evaluation of the antiproliferative potential of a single exercise bout needs technical improvement. Here, we present data of a pilot study showing how to evaluate the anti-cancer potential of single exercise bouts with an in vitro three-dimensional cell growth assay, using a triple-negative breast cancer cell line cultured with exercise-conditioned serum.

Keywords: Cell proliferation; Exercise; Three-dimensional in vitro culture; Triple negative breast cancer.