Cholinergic synapse pathway gene polymorphisms associated with allergen-induced late asthmatic responses

Ashwini Rajasekaran; Daniel He; Alice Yue; Amrit Singh; Casey P Shannon; J Mark FitzGerald; Louis-Philippe Boulet; Paul M O'Byrne; Gail M Gauvreau; Scott J Tebbutt

doi:10.1183/23120541.00107-2019

Cholinergic synapse pathway gene polymorphisms associated with allergen-induced late asthmatic responses

ERJ Open Res. 2019 Nov 4;5(4):00107-2019. doi: 10.1183/23120541.00107-2019. eCollection 2019 Oct.

Authors

Ashwini Rajasekaran^{1

2}, Daniel He^{1

2}, Alice Yue^{2

3}, Amrit Singh^{1

2

4}, Casey P Shannon^{1

2}, J Mark FitzGerald^{5

6}, Louis-Philippe Boulet⁷, Paul M O'Byrne⁸, Gail M Gauvreau⁸, Scott J Tebbutt^{1

2

6}

Affiliations

¹ Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
² Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, BC, Canada.
³ School of Computing Science, Simon Fraser University, Burnaby, BC, Canada.
⁴ Dept of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
⁵ Vancouver Coastal Health Research Institute, Vancouver General Hospital, Vancouver, BC, Canada.
⁶ Dept of Medicine, Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada.
⁷ Québec Heart and Lung Institute, Laval University, Québec City, QC, Canada.
⁸ Dept of Medicine, McMaster University, Hamilton, ON, Canada.

Abstract

Cholinergic synapse pathway gene polymorphisms may play a role in regulating a type of asthmatic airway response triggered upon allergen challenge http://bit.ly/2lJx1VG.