IgE-mediated allergy to proton pump inhibitors with both delayed and immediate onset

Leyla Barakat; Maria João Vasconcelos; Jean Luc Bourrain; Pascal Demoly; Anca-Mirela Chiriac

doi:10.5415/apallergy.2019.9.e30

IgE-mediated allergy to proton pump inhibitors with both delayed and immediate onset

Asia Pac Allergy. 2019 Oct 14;9(4):e30. doi: 10.5415/apallergy.2019.9.e30. eCollection 2019 Oct.

Authors

Leyla Barakat¹, Maria João Vasconcelos², Jean Luc Bourrain¹, Pascal Demoly^{1

3}, Anca-Mirela Chiriac^{1

3}

Affiliations

¹ Centre Hospitalier Universitaire de Montpellier, Hôpital Arnaud-de-Villeneuve, Département de Pneumologie et Addictologie, unité Exploration des Allergies, 34295 Montpellier, France.
² Serviço de Imunoalergologia, Centro Hospitalar de São João E.P.E; Porto, Portugal.
³ Sorbonne Université, INSERM, Institut Pierre-Louis D'épidémiologie et de Santé Publique, équipe EPAR, 75013 Paris, France.

Abstract

Proton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal diseases. Incidence of drug hypersensitivity reactions (DHRs) to PPIs has been rising, presumably because of their increased consumption. Most DHR are IgE-mediated, with half of the reactions being anaphylactic. We describe the case of a Caucasian 50-year-old female patient referred to our allergy department after 2 episodes of anaphylaxis. The allergy work-up distinguished PPI as a cause of delayed onset (14 hours) and immediate onset (45 minutes) IgE-mediated DHR.

Keywords: Anaphylaxis; Drug hypersensitivity; Hypersensivity, Delayed; Proton pump inhibitors; Skin tests.

Publication types

Case Reports